ML349,890819-86-0

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ML349

CAS No. : 890819-86-0

MCE 国际站：ML349

产品活性：ML349 是一个有效且特异的酰基蛋白硫酯酶 2 (APT2)/溶血磷脂酶 2 (LYPLA2) 抑制剂，其 K_i 值为 120 nM。ML349 也是 LYPLA2 的抑制剂，其 IC₅₀ 值为 144 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phospholipase

In Vitro: ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with K_is of >10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC₅₀s of >3000 and 144 nM, respectivley. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.

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