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10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥658.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥550.0 |
| 规格： | 10 mg | 产品价格： | ￥910.0 |
| 规格： | 25 mg | 产品价格： | ￥1730.0 |
| 规格： | 50 mg | 产品价格： | ￥2680.0 |
| 规格： | 100 mg | 产品价格： | ￥3966.0 |
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TM5275 sodium
CAS No. : 1103926-82-4
MCE 国际站：TM5275 sodium
产品活性：TM5275 sodium是纤溶酶原激活物抑制剂 (PAI-1)，IC50值为6.95 μM。
研究领域：Metabolic Enzyme/Protease
作用靶点：PAI-1
In Vitro: Docking studies shows that TM5275 binds to strand 4 of the A β-sheet (s4A) position of PAI-1. TM5275 is a selective PAI-1 and (up to 100 μM) does not interfere with other serpin/serine protease systems. TM5275 at concentrations of 20 and 100 μM significantly prolongs the retention of tPA-GFP on VECs by inhibiting tPA-GFP-PAI-1 high-molecular-weight complex formation. TM5275 enhances the time-dependent accumulation of plasminogen as well as the dissolution of fibrin clots on and around the tPA-GFP-expressing cells. Cell viability at 72 h treatment is decreased with 70-100 μM TM5275 in ES-2 and JHOC-9 cells. From 48 h up to 96 h, cell growth is suppressed with 100 μM TM5275. Active PAI-1 in cell culture media is significantly decreased in cells treated with 100 μM TM5275 compared to control treatment. TM5275 is suggested to exert anti-proliferative effects in ovarian cancer with high PAI-1 expression.
In Vivo: TM5275 exhibits a favorable pharmacokinetics profile and very low toxicity to mice and rats. In rat thrombosis models. Blood clot weights are significantly lower in rats administered 10 and 50 mg/kg of TM5275 (60.9±3.0 and 56.8±2.8 mg, respectively) than in vehicle-treated rats (72.5±2.0 mg). The antithrombotic effectiveness of TM5275 (50 mg/kg) is equivalent to that of ticlopidine (500 mg/kg), a reference antithrombotic compound. Plasma concentration of TM5275 reaches 17.5±5.2 μM after a dose of 10 mg/kg. TM5275 (5 mg/kg) combined with tPA (0.3 mg/kg) significantly enhances the antithrombotic effect of tPA (0.3 mg/kg) alone and provides a benefit similar to that of a high tPA dose (3 mg/kg).
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文献和实验CD82 分子 CD82 常用单克隆抗体或代号： 1A4,4F9;(R2) 主要表达细胞： Leu [B] 分子质量(kDa)和结构： gp50- 53(TM4-SF) 功 能： 淋巴细胞活化,信号传递 CD82 Aka prostate cancer antimetastasis gene KAI1, kang ai (Chinese for anticancer).
目的：克隆这个片断。 结果： 1, 5 TGTCTGGGTCTTGCACAATGACA 3 3 TCCGTTGTAGGTAGTATTTGGTC 5 rating L ength Tm GC% oD Ta opt sense 88 23 63.5 47.8 32.7 1 Anti-sense 100 23 60.8 43.5 33.6 1 product 82 406 88.2 49.0 55
8 Perform Melting Curve from 70 °C to 95°C； read every 0.3°C; Hold for 00:00:01 between reads. END 这一步是干什么用的？ 有的还有在预变性之前有一部50几度的退火温度？这步程序有必要吗？ 答复：82℃读板是为了消除可能存在的引物二聚体对实验的干扰。因为一般来说引物二聚体的TM值在80℃左右，产物的TM值多在85℃以上，这样如果是在72℃读板的话，得到的荧光值包括了引物二聚体和产物
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