Nevanimibe,133825-80-6

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Nevanimibe

CAS No. : 133825-80-6

MCE 国际站：Nevanimibe

产品活性：Nevanimibe (PD-132301) 是一种口服有效的，选择性酰基辅酶 A：胆固醇 O-酰基转移酶 1 (ACAT1) 抑制剂，EC₅₀ 为 9 nM。Nevanimibe 抑制 ACAT2，EC₅₀ 为 368 nM。Nevanimibe 诱导细胞凋亡 (apoptosis)，并具有抗肾上腺皮质癌的潜力。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Acyltransferase  |  Apoptosis

In Vitro: Coincubation of Nevanimibe (PD-132301; ATR101; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability.

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