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- MedChemExpress(MCE)
- 美国
- HY-U00458
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
TX-803
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1292821-90-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥962.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥590.0 |
| 规格： | 5 mg | 产品价格： | ￥1300.0 |
| 规格： | 10 mg | 产品价格： | ￥2080.0 |
| 规格： | 25 mg | 产品价格： | ￥4038.0 |
| 规格： | 50 mg | 产品价格： | ￥6000.0 |
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K-80003
CAS No. : 1292821-90-9
MCE 国际站：K-80003
产品活性：K-80003 有效抑制 tRXRα 依赖性的 Akt 激活和肿瘤细胞生长。
研究领域：PI3K/Akt/mTOR
作用靶点：Akt
In Vitro: When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization. Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions.
In Vivo: K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity to RXRα but lacks COX inhibitory activity.
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