Cbz-B3A,1884710-81-9

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Cbz-B3A

CAS No. : 1884710-81-9

MCE 国际站：Cbz-B3A

产品活性：Cbz-B3A 是 mTORC1 转导的有效选择性抑制剂，与泛素1、2、4 结合，Cbz-B3A 还能抑制 eIF4E 结合蛋白的磷酸化。

研究领域：PI3K/Akt/mTOR

作用靶点：mTOR

In Vitro: Cbz-B3A slows cellular growth of some human leukemia cell lines, but is not cytotoxic.
Cbz-B3A has a larger effect on the phosphorylation of 4EBP1 than p70^S6k compared to repamycin. Cbz-B3A inhibits mTOR through Ubiquilins.
Cbz-B3A decreases the incorporation of [³⁵S]methionine/cysteine into protein in a dose-dependent manner, with maximal inhibition of 68% observed at 10 μM, and an EC₅₀ of ~3 μM.

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