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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
38183-03-8
- 规格：
5 mg/10 mg/25 mg/50 mg/100 mg/500 mg
| 规格： | 5 mg | 产品价格： | ￥164.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥263.0 |
| 规格： | 25 mg | 产品价格： | ￥500.0 |
| 规格： | 50 mg | 产品价格： | ￥800.0 |
| 规格： | 100 mg | 产品价格： | ￥1226.0 |
| 规格： | 500 mg | 产品价格： | ￥3100.0 |
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7,8-Dihydroxyflavone
CAS No. : 38183-03-8
MCE 国际站：7,8-Dihydroxyflavone
产品活性：7,8-Dihydroxyflavone 是有效和选择性的 TrkB 激动剂，其模拟脑源性神经营养因子 (BDNF) 的生理作用。7,8-Dihydroxyflavone 有潜力用于各种神经疾病的研究。
研究领域：Neuronal Signaling | Protein Tyrosine Kinase/RTK | Apoptosis
作用靶点：Trk Receptor | Apoptosis
In Vitro: 7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis.
In Vivo: 7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease.?
Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease.
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