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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
ABT-869; AL-39324
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥800.0 |
| 规格： | 25 mg | 产品价格： | ￥1413.0 |
| 规格： | 50 mg | 产品价格： | ￥2150.0 |
| 规格： | 100 mg | 产品价格： | ￥3400.0 |
| 规格： | 200 mg | 产品价格： | ￥4918.0 |
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Linifanib
CAS No. : 796967-16-3
MCE 国际站：Linifanib
产品活性：Linifanib (ABT-869) 是一种高效、口服的 VEGFR 和 PDGFR 家族多靶点抑制剂，对 KDR、FLT1、PDGFRβ、FLT3 的 IC50s 分别为 4、3、66、4 nM。Linifanib 具有显著的抗肿瘤活性。Linifanib 对无关 RTKs、可溶性酪氨酸激酶或丝氨酸/苏氨酸激酶的活性要低得多。Linifanib 是一种特异的 miR-10b 抑制剂，阻断 miR-10b 的生物合成。
研究领域：Protein Tyrosine Kinase/RTK | Autophagy | Apoptosis
作用靶点：PDGFR | VEGFR | FLT3 | c-Fms | c-Kit | Autophagy | Apoptosis
In Vitro: Linifanib (0-10000 nM; 72 hours) inhibits in vitro the cell proliferation of 8305C and 8505C cell lines in a concentration-dependent manner.
?Linifanib significantly decreased the levels of phospho-CSF-1R after 24 h and 72 h in both 8505C and 8305C cells.
In Vivo: The synergistic ATC antitumor activity of linifanib (10 mg/kg; p.o.; daily for 33 days)/Irinotecan combination significantly increases the survival of ATC affected mice and induces some complete responses.
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