c-Met-IN-2,1635406-73-3

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c-Met-IN-2

CAS No. : 1635406-73-3

MCE 国际站：c-Met-IN-2

产品活性：c-Met-IN-2 是一种有效的，选择性的，可口服的 c-Met 抑制剂，IC₅₀ 值为 0.6 nM，具有抗肿瘤活性。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：c-Met/HGFR

In Vitro: c-Met-IN-2 (Compound 14) is a potent and selective c-Met inhibitor, with an IC₅₀ of 0.6 nM. c-Met-IN-2 also shows weak activity on other kinases, with IC₅₀s of 1075 nM (AxI), 731 nM (RON), 18364 nM (VEGFR2), 5396 nM (c-Kit), 2357 nM (PDGFRa), 17056 nM (c-Src).

In Vivo: c-Met-IN-2 (0.1, 1, 10 mg/kg, p.o., once daily) significantly reduces the volume of tumor in mice bearing H1993 tumors, and has similar effect in SNU-5 xenograft model via oral administration at 0.3, 1 and 3 mg/kg.

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