VEGFR-2-IN-9,408502-06-7

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VEGFR-2-IN-9

CAS No. : 408502-06-7

MCE 国际站：VEGFR-2-IN-9

产品活性：VEGFR-2-IN-9 (KDR-in-4) 是有效的激酶插入结构域受体 (KDR/VEGFR2) 抑制剂，IC₅₀ 值为 7 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：VEGFR

In Vitro: KDR (kinase insert domain-containing receptor) is one of the human tyrosine kinases that has a high affinity for vascular endothelial growth factor (VEGF) and is believed to be a primary mediator of tumor-induced angiogenesis.

In Vivo: KDR-in-4 may prove to be useful for the treatment of a variety of ocular neovascular diseases using a convenient oral dosing regimen. At doses of 100 mg/kg, KDR-in-4 results in a 98% reduction in lesion size in the rat choroidal neovascularization (CNV) model. 30 mg/kg doses of KDR-in-4 shows a 70% and 80% reduction in lesion size in the laser CNV and rat oxygen induced retinopathy (OIR) models, respectively.

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