JTE-952,1255303-54-8

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JTE-952

CAS No. : 1255303-54-8

MCE 国际站：JTE-952

产品活性：JTE-952 是 集落刺激因子-1 受体 (CSF-1R/cFMS) 有效的、具有口服活性的、 II 型 选择性抑制剂，其对 CSF1R 和 TrkA 的IC₅₀ 值分别为 13 nM 和 261 nM。可用于关节炎的相关研究。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：c-Fms

In Vivo: JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model).

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