JNJ-38877618,943540-74-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

JNJ-38877618

CAS No. : 943540-74-7

MCE 国际站：JNJ-38877618

产品活性：JNJ-38877618是一种有效的，高选择性的，口服可用的 (Met) 激酶抑制剂，对于野生型和突变体的 IC₅₀ 值分别为2和3 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：c-Met/HGFR

In Vitro: OMO-1 (formerly JNJ-38877618), is a potent, highly selective, orally bioavailable Met kinase inhibitor with nM binding affinity (K_d=1.4 nM) and enzyme inhibitory activity against wt and M1268T mutant Met (2 and 3 nM IC₅₀). Met inhibitory effects are assessed in proliferation, colony formation and motility assays. JNJ-38877618 displays nM potency against Met Ampl/mutant and therapy resistant models.

In Vivo: JNJ-38877618 induces complete inhibition of tumor growth in 3 models: the SNU5 Met amp gastric, U87-MG HGF autocrine glioblastoma and Hs746T Met exon 14 skipping mutant gastric cancer. JNJ-38877618 induces regression of large Met amplified EBC-1 SqNSCLC where JNJ-38877618 leads to dose- and time-dependent inhibition of Met kinase activation, with the duration of target shut down considerably exceeding plasma exposure times. Combination treatments are well tolerated and improved EGFR targeted therapy.

相关产品：Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Orally Active Compound Library  |  Anti-Lung Cancer Compound Library  |  Angiogenesis-Related Compound Library  |  Targeted Diversity Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Cancer Stem Cells Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Cytokine Inhibitors Library  |  Afatinib  |  Cabozantinib  |  Crizotinib  |  Capmatinib  |  Foretinib  |  Savolitinib  |  Tivantinib  |  Merestinib  |  PHA-665752  |  BMS 777607  |  SU11274  |  JNJ-38877605  |  Glesatinib hydrochloride  |  Golvatinib  |  Terevalefim  |  Amuvatinib  |  Ensartinib dihydrochloride  |  Altiratinib  |  Zanzalintinib  |  SRI 31215 TFA  |  Glumetinib  |  AMG-337  |  SGX-523  |  Bozitinib  |  Elzovantinib  |  MK-2461  |  PF-04217903  |  SCR-1481B1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds