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- 2025年12月05日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1432597-26-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥858.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥354.0 |
| 规格： | 5 mg | 产品价格： | ￥780.0 |
| 规格： | 10 mg | 产品价格： | ￥1350.0 |
| 规格： | 25 mg | 产品价格： | ￥2700.0 |
| 规格： | 50 mg | 产品价格： | ￥4600.0 |
| 规格： | 100 mg | 产品价格： | ￥5988.0 |
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LDN-212854
CAS No. : 1432597-26-6
MCE 国际站：LDN-212854
产品活性：LDN-212854 是一种骨形态发生蛋白 (BMP) 抑制剂，可有效抑制 ALK2 (IC50: 1.3 nM)。LDN-212854 还可抑制 ALK1 (IC50: 2.40 nM)。LDN-212854 可用于研究进行性骨化纤维发育不良和癌症，如肝细胞癌 (HCC)。
研究领域：TGF-beta/Smad
作用靶点：TGF-β Receptor
In Vitro: LDN-212854 (0-3.815 μM) blocks the phosphorylation of SMAD1/5/8 induced by BMP7 in BMPR2−/− cells.
LDN-212854 (2.5 μM, 5 days ) inhibits cell proliferation in Huh7 and MT cells.
LDN-212854 (0.5 μM, 48 h ) suppresses ID1 and EpCAM expression in Huh7 and MT cells.
In Vivo: LDN-212854 (intraperitoneal injection, 6 mg/kg, twice daily for 4 weeks) potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.
LDN-212854 (intraperitoneal injection, 6 mg/kg, twice daily for 10-14 days) suppresses HCC tumor progression through repression of ID1 in HCC xenografts model.
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