Eldecalcitol艾地骨化醇,104121-92-8

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Eldecalcitol

CAS No. : 104121-92-8

MCE 国际站：Eldecalcitol

产品活性：Eldecalcitol (ED-71) 是一种具有口服活性维生素 D3 类似物，可抑制骨吸收并增加骨密度。Eldecalcitol 具有抗肿瘤作用，抑制细胞增殖、迁移，并通过抑制 GPx-1 来诱导细胞凋亡 (apoptosis)。

研究领域：Vitamin D Related/Nuclear Receptor  |  Apoptosis

作用靶点：VD/VDR  |  Apoptosis

In Vitro: Eldecalcitol (0-50 nM; 24 h) displays no cytotoxicity, and (0.5-50 nM; 24 h) reduces cell death induced by LPS (5 μg/mL).
Eldecalcitol (5 nM; 24 h) inhibits the LPS-induced pyroptosis by activating Nrf2 and its effector molecule HO-1.
Eldecalcitol (0.5-50 nM; 24 h) exhibits anti-pyroptotic ability, and decreases NLRP3, caspase-1, and IL-1β expression dose-dependently.
Eldecalcitol (0.04-40 nM; 0-48 h) inhibits the proliferation and migration of SCC-15 and CAL-27 cells.
Eldecalcitol (0.4 nM; 48 h) arrests cell cycle at G0/G1 phase and induces apoptosis by suppressing the expression of GPx-1 (glutathione peroxidase) in OSCC cells.

In Vivo: Eldecalcitol (0.5 μg/kg; p.o.; twice a week for 4 weeks) displays anti-cancer effect by GPX-1 (glutathione peroxidase) inhibition.
Eldecalcitol (10, 30, or 90 ng/kg; p.o.; 5-times per week for 12 weeks), as a more potent vitamin D3 analog, stimulates focal bone formation (minimodeling) and suppresses bone resorption more strongly than does calcitriol.

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