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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Cytidine diphosphate-choline; CDP-Choline; Cytidine 5'-diphosphocholine
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
987-78-0
- 规格：
10 mM * 1 mL/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥474.0 |
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Citicoline
CAS No. : 987-78-0
MCE 国际站：Citicoline
产品活性：Citicoline (Cytidine diphosphate-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体。发挥神经保护作用。
研究领域：Apoptosis | Metabolic Enzyme/Protease
作用靶点：Apoptosis | Endogenous Metabolite
In Vitro: To determine the potential neuroprotective activity of Citicoline and Homotaurine, treated retinal cells are treated with increasing concentrations of Citicoline or Homotaurine for 24 hours. 1 μM, 10 μM and 100 μM of Citicoline or Homotaurine are used to investigate whether may contribute to a reduced cell viability in retinal cells. Retinal cells are well preserved in Citicoline- or Homotaurine-treated cultures, with no evidence of toxicity or significant loss of viability after treatments. 100 μM of Citicoline is not harmful to retinal neuroglial cells in vitro and 100 μM of Homotaurine is an effective concentration to enhance neuroprotection in a model of experimental glaucoma. Therefore, this concentration of Citicoline and Homotaurine is used for all subsequent experiments. To evaluate whether cotreatment with Citicoline and Homotaurine is able to induce a synergistic neuroprotective effect against glutamate excitotoxicity, retinal cell cultures are exposed to Citicoline 100 μM, Homotaurine 100 μM, and Citicoline+Homotaurine 100 μM, 24 hours before glutamate treatment. In the presence of 100 μM Citicoline, a significant increase in cell viability is observed.
In Vivo: Administration of Citicoline in a dose of 1000 mg/kg produces more pronounced increase in the threshold of clonic seizures and tonic phase of seizures with lethal outcome (by 18.54 and 50.08% respectively, in comparison with the control). The anticonvulsant effect is most pronounced after injection of Citicoline in a dose of 1000 mg/kg.
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文献和实验.3±10.224.7±9.62(10.0-54.0)0.46±0.130.49±0.12(0.20-0.80)78.0±14.071.0±16.0(50.0-135)15.5±4.4413.8±4.15(5.0-29.0)1.99±0.251.79±0.24(1.20-7.50)147±2.65146±2.50(143-156)5.82±0.116.60±0.12(5.40-7.00)102±0.85101±0.95(100-110)24.0±3.8020.8±3.60(12.6-32
%(w/w) 85.394 78.839 p (g/ml) 18o C 1.0831 1.1214 AcOK Potassium Acetate, KCH3 CO2 , Mw=98.15g/M; (store at NT). Conc. Stock %(w/w) 50ml 100ml 150ml KC2 H3 O2 1M 98.15g/M 9.38
， Briggs SP. 1992. Science，258:985～987 Jones D A et al， 1994. Science， 266:789～793 Jonsson J J， Weissman S M 1995. From mutation mapping to phenotype cloning. PNAS. 92， 83～85 Joshi C P et al， 1996. Plant Mol Biol， 30:641～646 Keller J et al， 1993
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