Ingliforib,186392-65-4

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Ingliforib

CAS No. : 186392-65-4

MCE 国际站：Ingliforib

产品活性：Ingliforib (CP 368296) 是一种 glycogen phosphorylase 抑制剂，对肝脏、肌肉和大脑 glycogen phosphorylase 的 IC₅₀ 值分别为 52，352 和 150 nM，具有心脏保护的作用。

研究领域：Others

作用靶点：Others

In Vitro: Ingliforib is a glycogen phosphorylase inhibitor, and inhibits the myocardial GP isoforms (muscle and brain) with IC₅₀s of 352 and 150 nM, respectively, also a potent inhibitor of the liver isoform (IC₅₀ of 52 nM). Ingliforib (0.1, 1, 10 μM) dose-dependently reduces infarct size in the isolated rabbit hearts.

In Vivo: Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits.

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