CB-6644,2316817-88-4

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CB-6644

CAS No. : 2316817-88-4

MCE 国际站：CB-6644

产品活性：CB-6644 一种选择性的 RUVBL1/2 复合体抑制剂。抑制 RUVBL1/2 的 ATP 酶活性，IC₅₀ 为 15 nM。具有抗癌活性。

研究领域：Others

作用靶点：Others

In Vitro: CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells.
?CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (including HCT116, NCI-1975, and HT29 cells) with an EC₅₀ range of 41 to 785 nM.

In Vivo: CB-6644 (150 mg/kg, oral administration, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models, 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models) has antitumor activity in xenograft tumor models with tumor growth inhibitions (TGIs) of 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.

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