Selpercatinib塞尔帕替尼,2152628-33-

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Selpercatinib

CAS No. : 2152628-33-4

MCE 国际站：Selpercatinib

产品活性：Selpercatinib (LOXO-292) 是一种有效的选择性 RET 激酶抑制剂，抑制 RET (WT)，RET (V804M) 和 RET (G810R)，其 IC₅₀ 值分别为 14.0 nM，24.1 nM 和 530.7 nM。Selpercatinib 具有抗肿瘤作用。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：RET

In Vivo: Selpercatinib (LOXO-292; 10 mg/kg; i.g.; for 0-2 h) has good pharmacokinetics after oral gavage in FVB/NRj mice.
Pharmacokinetic Parameters of Selpercatinib in FVB/NRj mice.

Administration	i.g. (10 mg/kg)
Tmax (h)	1.8
Cmax (ng/mL)	7862
AUC (ng·h/mL)	26649

FVB/NRj mice, 10 mg/kg i.g.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Drug Repurposing Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Targeted Therapy Drug Library   |  Targeted Diversity Library  |  Anti-Liver Cancer Compound Library   |  Rare Diseases Drug Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Lenvatinib  |  Regorafenib  |  Pralsetinib  |  TG101209  |  AST 487  |  Amuvatinib  |  BT-13  |  AD80  |  BBT594  |  GSK3179106  |  WHI-P180  |  WF-47-JS03  |  Zeteletinib  |  SPP-86  |  Vepafestinib  |  RET V804M-IN-1  |  RPI-1  |  Enbezotinib  |  NSC194598  |  Pz-1  |  BT44  |  Pyrazoloadenine  |  RET-IN-3  |  AD57

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds