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Selpercatinib
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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
LOXO-292
货期:1-2天
MedChemExpress LLC
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
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CAS No. : 2152628-33-4
MCE 国际站:Selpercatinib
产品活性:Selpercatinib (LOXO-292) 是一种有效的选择性 RET 激酶抑制剂,抑制 RET (WT),RET (V804M) 和 RET (G810R),其 IC50 值分别为 14.0 nM,24.1 nM 和 530.7 nM。Selpercatinib 具有抗肿瘤作用。
研究领域:Protein Tyrosine Kinase/RTK
作用靶点:RET
In Vivo: Selpercatinib (LOXO-292; 10 mg/kg; i.g.; for 0-2 h) has good pharmacokinetics after oral gavage in FVB/NRj mice.Pharmacokinetic Parameters of Selpercatinib in FVB/NRj mice.
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