SPEG (SPEG Complex Locus) is a Protein Coding gene. Diseases associated with SPEG include Centronuclear Myopathy 5 and Myopathy, Centronuclear, Autosomal Recessive. SPEG encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Along with the desmin gene, expression of this gene may be controlled by the desmin locus control region. Mutations in SPEG are associated with centronuclear myopathy 5.