Early and accurate measurement of Vitamin B12 deficiency is essential for preventing the occurrence of irreversible neurological dysfunction.
IBL International offers the Active-B12 (holotranscobalamin) ELISA for measuring Vitamin B12 which is bound to transcobalamin (TC), the only biologically active fraction that can be delivered to cells. Less than 30% of the total Vitamin B12 in plasma circulates as Active-B12 (HoloTC). The remaining 70% are bound to haptocorrin (HoloHC). Because changes
in HoloTC levels occur earlier than Total-B12 in Vitamin B12 depletion, it constitutes a faster way to prove Vitamin B12 deficiency. Independent clinical studies show the improved clinical diagnostic value obtained with measuring Active-B12 compared to assessing the Total Plasma Vitamin B12 concentration. The Active-B12