IL-1 beta 蛋白, Porcine

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IL-1 beta Protein, Porcine

MCE 国际站：IL-1 beta Protein, Porcine

IL-1 beta 是一种强效促炎细胞因子，由单核细胞、巨噬细胞和树突状细胞表达，在炎症和免疫反应中起关键作用。IL-1 beta 以无活性的 pro-IL-1β (由 pro-Il-1b 编码) 形式产生，以响应炎症刺激。IL-1 beta Protein, Porcine 由 153 个氨基酸(A115-P267) 组成，在大肠杆菌中表达。

Synonyms: rPoIL-1β; IL1B

Species: Porcine

Source: E. coli

Biological Activity: 1. The ED₅₀ is <1 ng/mL as measured by mouse D10S cells, corresponding to a specific activity of >1.0 × 10⁶ units/mg.
2. Measured by its ability to inhibit a cell proliferation assay using ATDC5 mouse chondrogenic cells. The IC₅₀ for this effect is 3.319 ng/mL, corresponding to a specific activity is 3.013×10⁵ units/mg.

研究背景：Interleukin-1β (IL-1β) is one of the pro-inflammatory cytokines and is produced and secreted by a variety of cell types although the vast majority of studies have focussed on its production within cells of the innate immune system, such as monocytes and macrophages.
IL-1β is produced as inactive pro-IL-1β (encoded by pro-Il-1b) in response to inflammatory stimuli, including both microbial products and endogenous danger-associated molecules. IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex inflammasome. Pro-Casp-1 (encoded by pro-Casp-1), activated by the inflammasome, cleaves pro-IL-1β into the bioactive IL-1β. IL-1β acts in an autocrine/paracrine manner via the type I IL-1 receptor (IL-1R1).
IL-1β could regulate the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. IL-1β also plays a significant regulator of reproduction in females.

蛋白编号：P26889 (A115-P267)

基因 ID：397122

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-1  |  白细胞介素-1 beta  |  细胞因子和生长因子  |  神经营养因子  |  白细胞介素-1  |  白细胞介素-1 beta

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-1  |  IL-1 beta  |  Cytokines and Growth Factors  |  Neurotrophic Factors  |  IL-1  |  IL-1 beta

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