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Anti-Cancer Compound Library
MCE 国际站:Anti-Cancer Compound Library
Cancer is the second leading cause of death globally and seriously threatens human health. A neoplasm and malignant tumor are other common names for cancer. Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Target therapy, which targets proteins that control how cancer cells grow, divide and spread, plays an important role in cancer treatment. Recent studies mainly focus on targeting the key proteins for cancer surviving, cancer stem cells, the tumor microenvironment, tumor immunology, etc.MCE designs a unique collection of 7284 anti-cancer compounds that target kinases, cell cycle key components, tumorigenesis related signaling pathways, etc. MCE Anti-cancer compound library is a useful tool for anti-cancer drug screening.
Description & Advantages:
• A unique collection of 7284 bioactive anti-cancer compounds for high throughput screening (HTS) and high content screening (HCS).
• Targets include kinases, cell cycle key components, tumorigenesis related signaling pathways, popular targets in epigenetic studies, and more.
• A useful tool for the discovery of anti-cancer drugs.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• Detailed compound information with structure, IC50, and brief introduction.
• Validated NMR and HPLC to ensure high purity and quality.
• All compounds are in stock and continuously updated.
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文献和实验whl111 P53蛋白具有肿瘤抑制作用,其机制可能是影响肿瘤细胞的凋亡。各位战友有没有想过如果将P53于体外直接作用于肿瘤细胞是不是会引起细胞的凋亡?而如果想办法让P53蛋白在体内能够接触到肿瘤细胞是不是可以起到抑制肿瘤细胞生长的作用呢? pub_wang 不太可能,其通路在肿瘤发生中已被打破,肿瘤中整个平衡都变了。 5米 一颗种子当它还是种子的时候,你把种子煮一下也许再也不会发芽,当这颗
抗肿瘤免疫效应机制 机体免疫系统识别肿瘤细胞表面表达的肿瘤抗原产生免疫应答,引起效应细胞的激活和释放一系列效应分子,攻击和清除肿瘤细胞、抑制肿瘤生长。这一应答能否有效地产生,取决于肿瘤细胞抗原性的强弱和宿主的免疫功能是否健全。 抗肿瘤免疫效应机制包括特异性和非特异性两方面。前者包括体液免疫和细胞免疫,其中细胞免疫发挥着抗肿瘤的主导作用.并与体液免疫相互调节,协同杀伤肿瘤细胞(图16-3)。后者包括Mφ NK细胞、中性粒细胞和多种
T 细胞介导的抗肿瘤免疫 T细胞在患者体内介导有效的抗肿瘤免疫是一个多步骤的过程: ①肿瘤抗原能够被提呈; ②肿瘤抗原能够到达引流淋巴结并被专职APC所提呈; ③肿瘤抗原特异性的T细胞能够增殖; ④受抗原刺激活化后的T细胞到达肿瘤组织; ⑤到达肿瘤组织的T细胞克服肿瘤微环境中抑制性的细胞因子,并且杀伤肿瘤组织; ⑥肿瘤应答免疫记忆细胞的产生。这些环节中任一步骤的缺失都将导致肿瘤
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