- ￥1350 - 3000
- Proteintech
- 26527-1-AP
- 2025年10月13日
- IHC, ELISA
- Rabbit
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human MIP-3α protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
IHC, ELISA
- 靶点：
CCL20/MIP-3 alpha
- 抗体英文名：
CCL20/MIP-3 alpha Polyclonal antibody
- 抗体名：
CCL20/MIP-3 alpha Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive IHC detected in | human lung cancer tissue, human pancreas cancer tissue, human tonsillitis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
26527-1-AP targets CCL20/MIP-3 alpha in IHC, IF, ELISA applications and shows reactivity with human samples.
| 经测试应用 | IHC, ELISA |
| 文献引用应用 | IHC, IF |
| 经测试反应性 | human |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag24069 Product name: Recombinant human MIP-3α protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 26-95 aa of BC020698 Sequence: ASNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | chemokine (C-C motif) ligand 20 |
| 别名 | CCL20, MIP-3 Alpha, MIP-3α, CCL-20, CCL 20 |
| 计算分子量 | 11 kDa |
| GenBank蛋白编号 | BC020698 |
| 基因名称 | CCL20/MIP-3 alpha |
| Gene ID (NCBI) | 6364 |
| RRID | AB_2880543 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P78556 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
CCL20, also known as macrophage infiltrating factor protein 3α, is a C-C chemokine that specifically binds to the receptor CCR6. CCL20 is produced in various tissues and by a wide range of immune cells, including neutrophils, natural killer cells, T-helper type 17 (Th17) cells, B cells, and various antigen-presenting cells, such as dendritic cells (DCs), Langerhans cells, and macrophages. Increased expression of CCL20 is likely involved in the increased recruitment of dendritic cells observed in fibroinflammatory diseases such as chronic obstructive pulmonary disease (COPD). CCL20 expression is increased by the proinflammatory cytokine IL-1 beta.
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文献和实验| Species | Application | Title |
|---|---|---|
| human | IF | Gut Microbes Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322/CCL20 axis and M2 polarizationAuthors - Chaochao Xu |
| human | IF | Front Cell Dev Biol EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.Authors - Bin Qi |
| mouse | Phytomedicine The secretion of sIgA and dendritic cells activation in the intestinal of cyclophosphamide-induced immunosuppressed mice are regulated by Alhagi honey polysaccharides.Authors - Gaofeng Cai | |
| human | IHC | Oncol Rep DEPDC1 drives hepatocellular carcinoma cell proliferation, invasion and angiogenesis by regulating the CCL20/CCR6 signaling pathway.Authors - Wubin Guo |
| human | IHC | Inflammation PMID: 31838663Authors - YingYing Hu |
| human | IHC | Oncol Lett Overexpression of B7-H4 promotes renal cell carcinoma progression by recruiting tumor-associated neutrophils via upregulation of CXCL8.Authors - Anqi Li |
, TCA3 (mouse) 单核细胞, T细胞 CCL2 SCYA2 MCP-1, MCAF, JE (mouse) 单核细胞, T细胞, 嗜碱细胞, 自然杀伤细胞, 祖细胞 CCL3 SCYA3 MIP-1, alpha MIP-1 alpha S, LD78 alpha
位升高），不知道我的这个结果是否可以说明gsk活性降低了？还是一定需要第九位的结果才能解释这个问题？似乎也有些人说216特异性不强，没有第九位有说服力，不是很能理解这其中的原因，再次感谢你！ ylhuang0502 As for the GSK phosphorylation, it is clear now that, GSK serine phosphorylation (S9 for beta and S21 for alpha
accumulation by LPS, as TLR4 can use either MyD88 or TRIF. The net result of these interactions was activation of the transcription factors NF-{kappa}B and AP-1, and synthesis of TNF-{alpha} mRNA. TNF-{alpha} acts through an apparent autocrine pathway
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