- ￥1350 - 3000
- Proteintech
- 19782-1-AP
- 2025年10月13日
- IHC, ELISA
- Rabbit
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
None
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
IHC, ELISA
- 靶点：
APC
- 抗体英文名：
APC Polyclonal antibody
- 抗体名：
APC Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive IHC detected in | human breast cancer tissue, human colon tissue, human colon cancer tissue, human endometrial cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:20-1:200 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
19782-1-AP targets APC in WB, IHC, ELISA applications and shows reactivity with human samples.
| 经测试应用 | IHC, ELISA |
| 文献引用应用 | WB |
| 经测试反应性 | human |
| 文献引用反应性 | human, mouse |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | adenomatous polyposis coli |
| 别名 | adenomatous polyposis coli, APC, BTPS2, Deleted in polyposis 2.5, DP2, DP2.5, DP3, GS, Protein APC |
| 计算分子量 | 312 kDa |
| GenBank蛋白编号 | NM_000038 |
| 基因名称 | APC |
| Gene ID (NCBI) | 324 |
| RRID | AB_2878605 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P25054 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
APC, also named as DP2.5, belongs to the adenomatous polyposis coli (APC) family. APC is a tumor suppressor that regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division, and associates with other proteins involved in cell attachment and signaling. APC promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. It plays a critical role in several cellular processes. APC regulates beta-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. APC activity is correlated with its phosphorylation state. Defects in APC are a cause of familial adenomatous polyposis (FAP) which includes also Gardner syndrome (GS). Defects in APC are a cause of hereditary desmoid disease (HDD) which also known as familial infiltrative fibromatosis (FIF). Defects in APC are a cause of medulloblastoma (MDB) which is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Defects in APC are a cause of mismatch repair cancer syndrome (MMRCS) which also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1).
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文献和实验| Species | Application | Title |
|---|---|---|
| human | WB | Mol Oncol Norepinephrine-CREB1-miR-373 axis promotes progression of colon cancer.Authors - Jia Han |
| human | WB | Biomed Pharmacother Glycogen phosphorylase B promotes ovarian cancer progression via Wnt/β-catenin signaling and is regulated by miR-133a-3p.Authors - Yang Zhou |
| human | WB | World J Gastroenterol MiR-205 mediated APC regulation contributes to pancreatic cancer cell proliferation.Authors - Rui-Feng Qin |
| human | WB | Cancer Med MiR-26b suppresses hepatocellular carcinoma development by negatively regulating ZNRD1 and Wnt/β-catenin signaling.Authors - Xiaobo Hu |
| human | WB | J Bone Oncol BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathwayAuthors - Hongting Guo |
| mouse | WB | Evid Based Complement Alternat Med Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model.Authors - Xuesong Yang |
1. T、B细胞相互作用的过程T细胞为Th2亚群，而B细胞既是Th细胞辅助的对象，又是T细胞活化的APC。这一相互合作包括一系列过程：①抗原以其B表位(绿色)与BCR结合传递B细胞活化的第一信号，使其C1340与细胞因子受体的表达增加，并使B细胞加工提呈抗原和表达少量D7分子；②B细胞作为APC将带有T表位(红色)的抗原肽提呈给CD4T细胞，供T细胞识别；③初步活化的T细胞表达CD40L等，与B细胞表面CD40结合成为B细胞活化的第二信号；④活化B细胞表达B7分子与CD28结合为T细胞提供第二
直接标记是最快速和最特异的磁标记方法。 2、间接标记 几乎所有的单克隆抗体或多克隆抗体都可以用于间接标记。用无标记的、生物素化的或FITC、PE或APC结合的一抗标记细胞，再用抗免疫球蛋白、抗生物素、链霉菌亲和素、抗FITC、抗PE、或抗APC的微珠分别进行磁标记。间接标记可以放大磁标记，用于分离表达比较弱的标记很有用。在间接标记中，以使用生物素化的或PE表记的一抗结果特异性最好
区、1个IgC样区、1个跨膜疏水区和1个由30个氨基酸组成的胞内区。不同于其他B7家族分子的是，它具有负向调节免疫应答的作用。PD-1和PD-L1是一对共抑制分子[3]。 这对共抑制分子，对癌细胞是如何发挥作用的呢。 憋急，听我慢慢道来！ 人类身体健康的卫士「T细胞」的活化是需要接收「双重信号」的：首先，T细胞表面受体（TCR）识别由抗原提呈细胞（APCs）提呈的抗原肽，使T细胞初步活化；然后，APC表面的共刺激分子与T细胞表面的相应共刺激分子结合，使T
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