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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
常温避光保存
- 保质期:
2年
- 库存:
大量现货
- 供应商:
上海钦诚生物
- CAS号:
33069-62-4
- 规格:
20mg
中文名称:紫杉醇
中文别名:泰素,紫素,特素
,浆果赤霉素III
英文名称:Paclitaxel
英文别名:
Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b?dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-
[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-; Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-
ester with (2R,3S)-N-benzoyl-3-phenylisoserine (8CI); 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.; (-)-Paclitaxel;
5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; ABI 007;Abraxane; BMS 181339-01; Capxol; Coroflex Please; Cyclopax; Cynviloq; Cypher select; DHP 107; Ebetaxel; EmPAC; EndoTAG 1; Genaxol;Genetaxyl; Genexol; Genexol-PM; IG 001; IG 002; Infinnium; Intaxel; LEP-ETU; Liposome-entrapped paclitaxel easy-to-use; MBT 0206; Mitotax; NK 105; NSC 125973; Nab-paclitaxel; Nanotax; Nanoxel; OncoGel; Onxal; PTX; Pacliex; Paclitaxel; Padexol; Paxene; Plaxicel; QW 8184; Sindaxel;TAXUS Express; TAXUS stent; TaxAlbin; Taxol; Taxol A; Taxus; Taxus Liberte; Tocosol Paclitaxel; Yewtaxan; Zisu
分子式:C47H51NO14
分子量:853.91
CAS号:33069-62-4
纯度: HPLC≥98%
外观:白色针晶粉
溶解性:不溶于水,易溶于氯仿、等有机溶剂,在碱性条件下很快分解。
Melting Point (Experimental)Value熔点: 213-216 °C (decomp)
Boiling Point (Predicted)Value沸点: 957.1±65.0 °C | Condition
Density (Predicted)Value密度: 1.39±0.1 g/cm3 | Condition: Temp: 20 °C
pKa (Predicted)Value值: 11.90±0.20 | Condition: Most Acidic Temp: 25 °C
旋光度:-49.0°~55.0°(甲醇)
储存条件: 2-8°C,干燥、避光、密封
规格: 20mg 50mg 100mg 500mg 1g 2g等应客户需求包装.
提取来源:属红豆属植物红豆杉(Taxus brevifolia)的树皮。
药理药效:紫杉醇主要适用于卵巢癌和乳腺癌,对肺癌、大肠癌、黑色素瘤、头颈部癌、淋巴瘤、脑瘤也都有一定疗效。
检测条件:甲醇:水(10:40:50)检测波长:228nm (仅供参考)
用途:用于含量测定、鉴别、药理实验、活性筛选等。
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文献和实验Synthesis and Biological Evaluation of a Paclitaxel Immunoconjugate
tissue. Small-molecule peptides as well as monoclonal antibodies have been used as TVs. The synthesis, antigen binding, and cytotoxicity of a covalent conjugate of the anticancer drug paclitaxel (taxol) to the anti-epidermal growth factor receptor (EGFR
Antisense Strategies for Redirection of Drug Metabolism: Using Paclitaxel as a Model
(paclitaxel; Fig. 1 ), an important antineoplastic agent that is used extensively in treating several types of malignancies including ovarian, breast, and lung, as well as melanomas (2 –5 ).
High-Performance Liquid Chromatographic Analysis of CYP2CSCatalyzed Paclitaxel 6-Hydroxylation
2C8, although studies with lmmunologically purified or cDNA-expressed CYP2C8 have indicated that this P450 catalyzes the metabohsm of retmol(6 ), retinolc acid (6 ), arachldonic acid (7 , 8 ), carbamazepine (9 ) and paclitaxel (10 –12 ). Oxldatlon
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