This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. 实验图 Western blot analysis with COX1 antibody at dilution at 1:1000 Immunohistochemistry of paraffin-embedded Breast cancer(hu) using COX1 at dilution of 1:100 (x100 lens,x200 lens). Immunohistochemistry of paraffin-embedded Pancreatic cancer(hu) using COX1 at dilution of 1:100 (x100 lens,x200 lens).