Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
蛋白分子量
52/76/61/65/82/86kDa
亚细胞定位
Cytoplasm Mitochondrion Nucleus Nucleus
免疫原
A synthetic peptide of human NR3C1
亚型
IgG
性状
液体
纯化方法
Affinity purification
背景资料
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.
Public Immunogen Range
30-80/777aa
克隆类型
Polyclonal Antibody
交叉反应
Human
应用
WB
规格
50ul 100ul
备注: 以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。 These protocols are for reference only. Solarbio does not independently validate these methods. 温馨提示: 使用前请离心。如有问题请及时联系我们。 Quick spin before use. If you have any questions, please contact us. 实验图 Western blot analysis with GCR antibody at dilution at 1:1000