Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位
Cytoplasm
免疫原
A synthetic peptide of human HMGCS1
亚型
IgG
性状
液体
纯化方法
Affinity purification
背景资料
HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
Public Immunogen Range
A synthetic peptide of human HMGCS1
克隆类型
Polyclonal Antibody
交叉反应
Human
应用
WB IHC
规格
50ul 100ul
备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示:
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图
Western blot analysis with HMGCS1 antibody diluted at 1:1000;Lane:Jurkat
Immunohistochemistry of paraffin-embedded Human stomach cancer with HMGCS1 antibody diluted at 1:50