为人尿或肾细胞的蛋白水解酶。天然底物是纤溶酶原。对湿敏感。溶于水。干粉在4℃较稳定,水溶液在4℃的稳定期为3天。Physical formLyophilized from 1mL of 50mM Tris-HCl,pH 7.4 with 100 mM NaCl,0.1% PEG 6000,and 200 mM mannitolPhysical propertiesHigh molecular weight form migrating at 54kDa by SDS-PAGE under non-reducing conditions
备注
Unit Definition
One unit will activate that amount of plasminogen which will produce a ΔA275 of 1.0 per ml per minute at pH 7.5 at 37℃,when measuring perchloric acid soluble products from α-casein(1cm light path).
生化机理
Urokinase expression and invasiveness suppression by urinary trypsin inhibitor acts through MEK/ERK/c-Jun-dependent signaling pathways