一种HIF-α脯氨酰羟化酶抑制剂,在无细胞实验中,稳定HIF-2,诱导EPO的产生并刺激红细胞生成。Roxadustat is an HIF α prolyl hydroxylase inhibitor in a cell-free assay. It stabilizes HIF-2 and induces EPO production and stimulates erythropoiesis. Roxadustat transiently and moderately increased endogenous erythropoietin and reduced hepcidin。