A-205804 is a potent and selective inhibitor ofE-selectinandICAM-1expression withIC50of 20 nM and 25 nM respectively.
生化机理
A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression(IC50 values are 20,25 and>1000 nM for TNF-α-induced E-selectin,ICAM-1 and VCAM-1 expression respectively).Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.