Rat Anti Mouse CD8 FITC

CD8, MAL, p32.

Rat Anti Mouse Monoclonal.

CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains bind to class-I MHC molecules alpha-3 domains.

NYRmCD8.

Purified Mouse LN T cells.

Rat IgM.

Ion Exchange Column.

1mg/ml in PBS (after reconstitution).

Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

FACS staining, immunohistochemistry, Western Blotting. For staining, use 10 µl/1,000,000 cells.

This antibody is only available unconjugated and conjugated to Biotin.

SDS

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