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Recombinant Human TRAF Family

Member-Associated NFKB Activator, (1-119 a.a.)
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  • ¥1080 - 40572
  • Prospecbio
  • 以色列
  • pro-685
  • 2025年07月18日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      for future use below -18°C

    • 保质期

      See instructions

    • 英文名

      TANK (1-119)

    • 库存

      常规产品有备货

    • 供应商

      上海经科化学科技有限公司

    • CAS号

    • 规格

      10ug/50ug/1mg

    规格:10ug产品价格:¥1080.0
    规格:50ug产品价格:¥2415.0
    规格:1mg产品价格:¥40572.0

    产品细节图片1

    CATALOGUE NUMBER

    PRO-685

    SYNONYMS

    TRAF2, I-TRAF, TANK, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, ITRAF.

    INTRODUCTION

    TRAF2 protein is related with transduce signals from members of the TNFR superfamily. TRAF2 is located in the cytoplasm binds to TRAF1, TRAF2, or TRAF3, thus inhibiting TRAF function by sequestering the TRAFs in a suppressed state in the cytoplasm. Overexpression of TANK inhibits TRAF2-mediated NF-Kappa-B activation signaled by CD40 and both TNF receptors and inhibits LMP1-mediated NF-kappa-B activation by blocking the association of TRAF2 with LMP1. TRAF2 is necessary for the cellular response to TNF-alpha by connecting upstream signalling molecules to the IKKs and p65.

    DESCRIPTION

    TANK produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids (1-119 a.a.) and having a molecular mass of 13.6 kDa.
    TANK is purified by proprietary chromatographic techniques.

    SOURCE

    Escherichia Coli.

    PHYSICAL APPEARANCE

    Sterile filtered colorless solution.

    FORMULATION

    The TANK protein solution contains 20mM Tris, pH-8.

    STABILITY

    Store at 4°C if entire vial will be used within 2-4 weeks.
    Store, frozen at -20°C for longer periods of time.
    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
    Avoid multiple freeze-thaw cycles.

    PURITY

    Greater than 90.0% as determined by SDS-PAGE.

    AMINO ACID SEQUENCE

    MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIASAESSI.

    SAFETY DATA SHEET

    SDS

    USAGE

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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    图标文献和实验
    该产品被引用文献

    TANK produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids (1-119 a.a.) and having a molecular mass of 13.6 kDa.
    TANK is purified by proprietary chromatographic techniques.

    相关实验
    • TRAF‐Mediated TNFR‐Family Signaling

        Figure 11.9.1 Domain organization of mammalian tumor‐necrosis factor receptor (TNFR)‐associated factors (TRAFs). The TRAF family consists of seven proteins. Each TRAF, except TRAF1, has a RING‐finger domain

    • 【信息】The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

      signalling 1), which interacts with MAL causing it to be degraded. TRIF is used by TLR3, and leads to the activation of IRF3 through TBK1 (TRAF-family-member-associated NF-B activator-binding kinase 1). It is also involved in the NF-B activation pathway

    • 【求助】NF-kB参于凋亡途径

      phosphorylate IkB leading to its ubiquitination and degradation. Tumor necrosis factor (TNF) which is the best-studied activator binds to its receptor and recruits a protein called TNF receptor death domain (TRADD). TRADD binds to the TNF receptor-associated

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    文献支持
    Recombinant Human TRAF Family Member-Associated NFKB Activator, (1-119 a.a.)
    ¥1080 - 40572