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Recombinant Human Mannose-6-Ph

osphate Receptor
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  • ¥1080 - 87906
  • Prospecbio
  • 以色列
  • pro-1961
  • 2026年01月20日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      for future use below -18°C

    • 保质期

      See instructions

    • 英文名

      M6PR

    • 库存

      常规产品有备货

    • 供应商

      上海经科化学科技有限公司

    • CAS号

    • 规格

      2ug/10ug/1mg

    规格:2ug产品价格:¥1080.0
    规格:10ug产品价格:¥2415.0
    规格:1mg产品价格:¥87906.0

    产品细节图片1

    CATALOGUE NUMBER

    PRO-1961

    SYNONYMS

    Mannose-6-Phosphate Receptor (Cation Dependent), CD-MPR, MPR46, CD Man-6-P Receptor, MPR 46, 46-KDa Mannose 6-Phosphate Receptor, MPR-46, SMPR, Cation-Dependent Mannose-6-Phosphate Receptor, Mr 46,000 Man6PR, Small Mannose 6-Phosphate Receptor, 46 KDa Mannose 6-Phosphate Receptor, MPRD, M6PR.

    INTRODUCTION

    Mannose-6-Phosphate Receptor (M6PR) belongs to the P-type lectin family. P-type lectins play a vital role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The M6PR protein functions as a homodimer and needs divalent cations for ligand binding. Lysosomal enzymes carrying phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the ensuing receptor-ligand complex is transferred to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

    DESCRIPTION

    M6PR Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 182 amino acids (27-185) and having a molecular mass of 20.3kDa.
    M6PR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    SOURCE

    Escherichia Coli.

    PHYSICAL APPEARANCE

    Sterile Filtered clear solution.

    FORMULATION

    The M6PR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

    STABILITY

    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
    Avoid multiple freeze-thaw cycles.

    PURITY

    Greater than 85.0% as determined by SDS-PAGE.

    AMINO ACID SEQUENCE

    MG.S.SHHHHHH SSGLVPRGSH MGSTEEKTCD LVGEKGKESE KELALVKRLK PLFNKSFEST VGQGSDTYIY IFRVCREAGN HTSGAGLVQI NKSNGKETVV GRLNETHIFN GSNWIMLIYK GGDEYDNHCG KEQRRAVVMI SCNRHTLADN FNPVSEERGK VQDCFYLFEM DSSLACSPEI SH.

    SAFETY DATA SHEET

    SDS

    USAGE

    Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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    图标文献和实验
    该产品被引用文献

    M6PR Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 182 amino acids (27-185) and having a molecular mass of 20.3kDa.
    M6PR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    相关实验
    • 甘露糖受体(mannose receptor,MR)

      甘露糖受体 (mannose receptor , MR) 主要表达在M中表面,为单链跨膜分子,结构不同于前面提到的甘露糖结合凝集素,其胞外段包括两种结构:一是8个C型凝集素结构域的连续排列,负责配体的内吞转运;二是远膜端富含胱氨酸的凝集素结构域,识别硫酸化的糖类偶联物 识别PAMP的甘露糖受体和清道夫受体丸甘露糖受体结构示意图。 胞膜外8个C型凝集素结构域连续排列,负责配体的内吞转运;远膜端为富含胱氨酸的凝集素结构域。 B清道夫受体A类中I型分子三螺旋聚合

    • Exploiting Fc Chimaeric Proteins for the Identification of Ligands Specific for the Mannose Receptor

      . In this chapter we describe our experience in the use of proteins containing selected regions of the mannose receptor fused to the Fc region of human IgG1 or murine IgG2b. Using these reagents we have discovered new and unexpected ligands for the mannose receptor

    • Expression and Purification of Recombinant Human Progesterone Receptor in Baculovirus and Bacterial Systems

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    文献支持
    Recombinant Human Mannose-6-Phosphate Receptor
    ¥1080 - 87906