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- enz-769
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
for future use below -18°C
- 保质期：
See instructions
- 英文名：
MMP2
- 库存：
常规产品有备货
- 供应商：
上海经科化学科技有限公司
- CAS号：
无
- 规格：
2ug/10ug/1mg
| 规格： | 2ug | 产品价格： | ￥1080.0 |
|---|---|---|---|
| 规格： | 10ug | 产品价格： | ￥2415.0 |
| 规格： | 1mg | 产品价格： | ￥87906.0 |
CATALOGUE NUMBER
ENZ-769
SYNONYMS
kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1, MMP2, CLG4A, CLG4, MONA, MMP-II.
INTRODUCTION
Matrix metalloproteinase-2 (MMP-2) is involved in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. MMP-2 contains a number of distinct domains: a prodomain that is cleaved upon activation; a catalytic domain containing the zinc binding site; a fibronectin like domain believed to have a role in substrate targeting; and a carboxyl terminal (hemopexin like) domain containing 2 N-linked glycosylation. The MMP-2 can degrade an extensive array of substrates including type IV, V, VII and X collagens as well as gelatin type I. In addition, MMP-2 interacts with THBS2, TIMP2, Thrombospondin 1, CCL7 and TIMP4. MMP-2 autocatalytic cleavage in the C-terminal generates the anti-angiogenic peptide, PEX. This process seems to be made possible by binding integrinv/beta3. Defects in the MMP-2 are the cause of Torg-Winchester syndrome (TWS), aka multicentric osteolysis nodulosis and arthropathy (MONA).
DESCRIPTION
SOURCE
PHYSICAL APPEARANCE
FORMULATION
STABILITY
Avoid multiple freeze-thaw cycles.
PURITY
AMINO ACID SEQUENCE
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文献和实验Title: Thrombin-dependent MMP-2 Activity Is Regulated by Heparan Sulfate
Publication: Journal of Biological Chemistry 285.53 (2010): 41270-41279.
Matrix Metalloproteinase Expression in Lung Cancer
. Table 1 Matrix Metalloproteinase Classifi cation MMP family MMP number Common name
Analysis of Matrix Metalloproteinase Secretion by Macrophages
Matrix metalloproteinases (MMPs) are zinc-dependent proteases whose physiological roles include control of leukocyte migration. They are implicated in tissue destruction in inflammatory and infectious diseases. MMPs are not only capable
Detection of Ovarian Matrix Metalloproteinase mRNAs by In Situ Hybridization
cells expressing the matrix metalloproteinases and their endogenous inhibitors, the TIMPs, in the human ovary.
技术资料