cancer. Oncogene 2022;41(5):745-756
Agents: 5-fluorouracil; Thiamet-G Vehicle: NaCl; Route: SC; Species: Mice; Pump: Not Stated; Duration: 13 days;
ALZET Comments: Dose (12.5 mg/kg/day); (90 mg/kg/
day); 0.9% sodium chloride used; animal info (C57BL/6J; 8 week male mice); cancer (colorectal);
Q10274: S. Hegde, et al. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes
resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia 2022;36(3):637-647
Agents: IODVA1; Imatinib Vehicle: Not Stated; Route: SC; Species: Mice; Pump: Not Stated; Duration: 28 days;
ALZET Comments: Controls received mp w/ vehicle; animal info (Vav3-deficient mice and Rac1Δ/Δ+Rac2-deficient mice;
C57Bl/10 (females, 8–16 weeks old) and NSG (NOD/SCID/IL2RG-/- males and females, 8–14 weeks old); IODVA1 aka
2-guanidinobenzimidazole derivative with anti-tumorigenic properties; cancer (leukemia)