产品名称:Rabbit anti-Human Programmed cell death 1 Ligand 1 (PDL1/CD274) antibody
Host: Rabbit
Clonality: Polyclonal
Purification: Ammonium sulfate followed by peptide affinity purification
Immunogen: Mix of 2 synthetic peptides, one derived from the extracellular and one from the cytoplasmic region of Human PD-L1
Species Reactivity: Human
Cross reactivity: The peptide used as an immunogen exhibits the % homology with the species as follows; 100% Chimpanzee, Gibbon, Bonbo. 95% Elephant Shrew, 94% Rabbit, 89% Rhesus, 95% Horse, 94% Dog, and 88% Pig for the extracellular peptide. Reactivity has only been confirmed in human samples. Due to the high homology, it is expected to react with the above species.
Subcellular Location: Plasma membrane
Alternative names: PDCD1 Ligand 1, B7 homolog 1, CD274
Recommended Secondary Antibody: Goat anti-Rabbit IgG-HRP (ADI cat#20320)
Negative Control: Non-immune Rabbit IgG (ADI cat# 20009-1).
产品描述:Programmed cell death protein 1, also known as PD-L1 and CD274 (cluster of differentiation 279), is a protein that is speculated to play a role in suppressing the immune system during disease states such as tissue allografts and autoimmune diseases. Normally the immune system reacs to foreign antigens by triggering a proliferation of antigenspecific CD4+ and CD8+ T cells. The binding of PD-L1 transmits an inhibitory signal that reduces the proliferation of antigen specific T-cells while reducing apoptosis in regulatory T- cells. Upregulation of PD-L1 has been speculated to allow different cancers to evade the host immune system. Currently, many PD-L1 inhibitors are in development as immuno-oncology therapies and have shown promising results in clinical trials.