Human SC5b-9 Complex cat#127

Complement Technology, Inc. (CompTech) 致力于为生物医学研究界提供高质量的补休试剂，补体领域有超过80年的经验。公司是是销售的补体试剂的原始制造商。

Vitronectin (S Protein) binds to membrane attack complexes that fail to insert into membranes. The result is a soluble complex of S Protein and C5b-9 and this has been named SC5b-9 (Dodds, A.W. and Sim, R.B. (1997)). Activation of complement in the absence of bilipid layer membranes results in most of the activated C5 forming SC5b-9 complexes. This can occur with activating particles such as immune complexes, yeast and bacterial cell walls. The SC5b-9 complexes can have more than one C9 (usually three) and more than one S Protein (usually three) per complex. Thus, the typical molecular weight is ~1,030,000 Da.

One C5b-7 complex can bind up to three molecules of S Protein. If C8 or C8 and C9 have already bound to the C5b-7 complex three S Protein molecules will bind to these complexes as well. The C5b6 and C5b-7 complexes sometimes diffuse away from the target cell and enter the membrane of a nearby cell. This is called bystander lysis or “reactive lysis” and can be a significant source of pathology. Binding of S Protein blocks this non-specific lysis. Diffusion of these early complexes away from the activating surface may result in addition of C8 and C9 to the complex prior to S Protein binding. Once S Protein binds to these complexes it prevents their membranolytic functions, thus creating soluble complexes that are subsequently cleared from circulation.

Catalog #:A127
Sizes Available:100 µg/vial
Concentration:1.0 mg/ml