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- ALZET缓释给药胶囊，缓释胶囊泵 Alzet Osmotic Pumps
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- 2026年02月03日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 库存：
100
- 国食药监械注册号：
无
- 保修期：
12个月
- 现货状态：
ALZET缓释给药胶囊，缓释胶囊泵 Alzet Osmotic Pumps
- 供应商：
玉研仪器公司
- 规格：
敬请来电咨询
ALZET 小动物缓释给药胶囊，也叫做渗透压微量给药胶囊泵 (ALZET Osmotic Pumps, Implantable Pumps，Alzet Osmotic Pumps）体积只有胶囊大小，可植入实验动物皮下或腹腔内或背部 , 直接或通过导管以 ul / 小时的速度持续准确地送出测试药剂，最长可达 6 个星期。
ALZET 小动物缓释给药胶囊有上万篇文献支持，操作方便，数据可靠。根据给药速度和给药量，有多种型号可选。
在全球各地八千项生命科学实验研究中 , Alzet pumps 已成功的运送上百种药剂，包括蛋白质 , 多肽 , 生长因子 , 基因研究及治疗中的 Antisense 和 干扰 RNA ( RNAi), 抗生素 , 化疗药 , 激素 , 类固醇及其它短效期的化合物。特别在心血管疾病及神经系统疾病的研究中 , 通过 ALZET Osmotic pumps 持续给药可以建立多种疾病的动物模型 , 如高血压及 Parkinson 帕金森病的动物模型。
Alzet Osmotic Pumps 符合 USP 医疗用塑胶材料生物兼容性标准，适合植入实验动物体内，针对特定部位给药 ， 或将药剂用导管导入作用部位 , 例如 : 脊髓及颅腔内 , 血管内 , 肝脏 , 脾脏及其它脏器和创伤处。
Alzet 脑部输液导管，传递试验物质到 CNS(中枢神经系统)
在全球各地八千项生命科学实验研究中 , Alzet pumps 已成功的运送上百种药剂，包括蛋白质 , 多肽 , 生长因子 , 基因研究及治疗中的 Antisense 和的干扰 RNA ( RNAi), 抗生素 , 化疗药 , 激素 , 类固醇及其它短效期的化合物。特别在心血管疾病及神经系统疾病的研究中 , 通过 ALZET Osmotic pumps 持续给药可以建立多种疾病的动物模型 , 如高血压及 Parkinson 帕金森病的动物模型。
· 用 ALZET ® Osmotic Pumps 发表的科学论文已达一万多篇。
· 采用植入式胶囊渗透压泵 ALZET ® Osmotic Pumps 输送药物进行药理生理及毒理实验的中国国立研究机构和大学及药厂研究室已达 100 多家。
· 在生命科学实验研究中 , 植入式胶囊渗透压泵 Alzet pumps 己成为输送药物的良好工具。
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ALZET微渗透压泵的优点 |
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Alzet Osmotic Pumps符合 USP 医疗用塑胶材料生物相容性标准，适合植入实验动物体內，针对特定部位給药，或將药剂用导管导入作用部位, 例如: 脊髓及颅腔内, 血管内, 肝脏, 脾脏及其它脏器肿瘤和创伤处。
Alzet Osmotic Pumps渗透压泵的技术参数:
多种型号可选
AlZET脑输注附件套
ALZET微渗透压泵通过脑输注附件套，进行直接的脑部药物输注。已经有成百上千关于神经科学的文献发表，输注的药物包括生长因子，siRNA，精神药物等。
Alzet 脑部输液导管，传递试验物质到 CNS(中枢神经系统)
可将药剂用导管导入不同的作用部位, 例如: 颅腔及脊髓内, 血管内, 肝脏,脾脏及其它脏器和创伤处。
Alzet Osmotic Pumps符合 USP 医疗用塑胶材料生物相容性标准，适合植入实验动物体內，针对特定部位給药，或將药剂用导管导入作用部位, 例如: 脊髓及颅腔内, 血管内, 肝脏, 脾脏及其它脏器肿瘤和创伤处。
研究应用：
| -给药 -生物工艺学 -癌症研究 -心血管研究 -内分泌研究 -基因治疗 -免疫研究 -神经科学 -药理学 -生理学 -毒力学 -体外研究 -裸鼠 |
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明胶灌胃胶囊
动物明胶给药胶囊，非常适合对大鼠、小鼠进行胶囊式口部给药。
先对药物进行胶囊灌装，再对大鼠或小鼠进行给药操作。
玉研仪器公司还提供国产订制型胶囊：肠溶性、胃溶性的大小鼠灌胃胶囊，一共四种型号，敬请来电咨询。
对大鼠、小鼠、豚鼠进行消化道（胶囊）给药：
粉末或者固体的药物，或者无法用导管进行投药的情况下，使用胶囊就可以轻松投药；
对应一些有臭味或者苦味的药剂，能够简单投药，减轻动物的痛苦；
个别制剂类药物的投药相当便利；
为了能够长时间持续的发挥药效，胶囊可以辅助充分吸收；
实验规程中必须要用胶囊进行投药的情况下，是最适合的；
与药物混在饲料中进行喂食相比，用胶囊的方法更精准且无残留；
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- 作者
- 内容
- 询问日期
文献和实验ALZET 缓释给药胶囊部分文献：
Basic fibroblast growth factor (FGF) promotes cartilage repair in vivo
... Alzet osmotic pumps delivering the mitogen to the site of injury promotes the healing of
intra-chondrial lesions by stimulating chondrocyte proliferation and the formation of extracellular matrix. ... Amer. J. Pathol., 81 (1975), pp. 337–346. Copyright © 1988 Published by Elsevier Inc. ...
An essential role for interferon gamma in resistance to Mycobacte*rium tubercu*losis infection.
... studies of murine IFN--y performed by Sharon Chen (Genentech, Inc., South San ... For continuous infusion, mice were subcutaneously implanted with osmotic pumps (Alza Corp., Palo Alto, CA...(B) gko mice were implanted subcutaneously with Alzet osmotic pumps loaded with IFN ...
The in‐vivo evaluation of an osmotic device (Osmet) using gamma scintigraphy
... 1 Alzet and Osmet are trademarks. ... DISCUSSION In the operation of the Osmet device, water is osmotically imbibed across the semipermeable mem- brane, swelling the osmotic
compartment and squeezing the drug reservoir uniformly along the axis. ...
… induced cell proliferation in rodent liver and kidney: a comparison of 5-bromo-2′-deoxyuridine and [3H] thymidine administered by injection or osmotic pump
... 2 h pulse 3 day pump 6 day pump 3 day pump; 3 weeks0 ... approximately 9 am, a second set of animals were implanted with pumps to deliver label for 3 days (Alzet models 1003D ... Product specifications state that osmotic pumps begin continuous delivery — 4 h after implantation. ...
Oral controlled‐release delivery of ivermectin in cattle via an osmotic pump
... Drug Delivery Device-Ivermectin was administered as a micel- lar solution contained within an ALZET 2ML4 mini-osmotic pump (ALZA Corp., Palo Alto ... The osmotic pumps were filled with the appropriate concen- tration of ivermectin solution to ensure that the defined dose ...
Osmotic drug delivery: a review of the patent literature
G Santus, RW Baker - Journal of Controlled Release, 1995 - Elsevier
... Water is drawn by osmosis into the salt chamber through semipermeable membrane. ... Coating containing solid osmotic compound ... Small pumps of this form are sold under the trade name Alzet® and are frequently used as implantable controlled-release delivery systems in ...
The impact of co-solvents and the composition of experimental formulations on the pump rate of the ALZET® osmotic pump
... the aqueous sodium chloride solution was needed for the initiation of the pumping and was ...facilitating the screen of lipophilic, poorly water-soluble compounds in osmotic pump studies ... ALZET,1992; ALZET Osmotic Pumps, Technical Information Manual, ALZA Corporation, 1992 ...
Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity
... 88 was continually administered to the animals by ip-inserted 14-day Alzet mini-osmotic ... Detected by phycoerythrin-coupled rabbit F(ab′) 2 antimouse immunoglobulin (DAKO Corp., Carpinteria, CA ... at a dose of 20 mg/kg/day via ip 7-day mini-osmotic pumps (Alza Corporation). ...
Correlation of iron and zinc levels with lesion depth in newly formed atherosclerotic lesions
... Six weeks into the high cholesterol diet, two groups were treated with the iron chelating agent desferrioxamine, for 2 weeks and 4 weeks, respectively, by surgically implanting with Alzet osmotic pumps (Alza Corporation, Palo Alto, CA, USA) containing desferal (0.5 g/ml). ...
immune responses. This model shows inflammation and extracellular matrix deposition, and upregulated expression of genes associated with fibrosis and vascular injury. We detail here the methodology for this model, utilizing osmotic pumps to deliver innate
Intracerebral Infusion of Neurotrophic Factors
of commercially available Alzet osmotic pumps that are placed under the skin and are connected to commercially available metal infusion cannulas whose tip can be stereotactically placed in virtually any location of the brain. Different
engineered cells, biomaterials, and osmotic pumps. The osmotic pump (Durect, Cupertino, CA, USA) consists of a semipermeable hard outer shell, a compressible inner bag that will contain the biological factor, and a high-osmolarity substance
技术资料