NLRC3 rabbit polyclonal antibo

gene_symbol：NLRC3
predicted_size：null
Uniprot ID：Q7RTR2
description：NLRC3 rabbit polyclonal antibody, Purified
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-?B, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
immunogen：Synthetic peptide - KLH conjugated
recommended_dilution：ELISA. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1 - 2 µg/ml.
predicted_size：null
buffer：PBS containing 0.02% Sodium as preservative; State: Purified; State: Liquid purified Ig fraction.
host_species：Rabbit
applications：ELISA, IHC, WB
reactivities：Human, Mouse, Rat