重组人Fc gamma RIIIA(CD16a)(FCGR3

特别提示：包括重组人Fc gamma RIIIA(CD16a)(FCGR3A)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人Fc gamma RIIIA(CD16a)(FCGR3A)
英文名称：Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A
产品货号：JN1829
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gly17-Gln208在C端含有His标签。

Fc gamma RIIIA/CD16a/FCGR3A质量控制：＞95%(还原性SDS-PAGE)

Fc gamma RIIIA/CD16a/FCGR3A制剂：冻干品

Fc gamma RIIIA/CD16a/FCGR3A保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Fc gamma RIIIA/CD16a/FCGR3A复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Fc gamma RIIIA/CD16a/FCGR3A：
Receptors for the Fc region of immunoglobin G (FcγR) are divided into three classes and FcγRIII is a multifunctional, low/intermediate affinity receptor. In humans, FcγRIII is expressed as two distinct forms (FcγRIIIA and FcγRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. FcγRIIIB is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas FcγRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The FcγRIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. FcγRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. In humans, it is a 50 -70 kD type I transmembrane activating receptor. The FcγRIIIA cDNA encodes 254 amino acid including a 16aa signal sequence, 191 amino acid ECD with two C2-type Ig-like domains, five potential N-glycosylation sites, a 22 amino acid transmembrane sequence and a 25 amino acid cytoplasmic domain.


除了重组人Fc gamma RIIIA(CD16a)(FCGR3A),，我公司还供应以下相关产品：



名称：重组人趋化因子CXCL10(IP-10)
货号：JN0288
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Val22-Pro98表达纯化而来。

CXCL10/IP-10质量控制：＞95%(还原性SDS-PAGE)。

CXCL10/IP-10制剂：冻干品

CXCL10/IP-10保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

CXCL10/IP-10复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于CXCL10/IP-10：
Human C-X-C Motif Chemokine Ligand 10 (CXCL10) is a non-ELR chemokine secreted by various cell types, such as monocytes, endothelial cells and fibroblasts, in response to IFN-γ. CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles, such as chemoattraction for activated T-lymphocytes, inhibition of angiogenesis, and antitumor activity.

名称：重组人BAMBI
货号：JN0626
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备而成(人类细胞)。目的蛋白包含序列(Val21-Ala152)在C端含有His标签。

BAMBI质量控制：＞95%(SEC-HPLC，还原性SDS-PAGE)


BAMBI制剂：冻干品

BAMBI保存：
冻干蛋白长期保存应置于-20℃以下，常温可稳定保存3周。
复溶蛋白溶液可在4℃保存2～7天。
复溶后的蛋白溶液应尽量避免反复冻融，可根据使用量分装冻存在-20℃以下长达3个月。

BAMBI复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
Dissolve the lyophilized protein in 1X PBS.
复溶后，请根据用量分装冻存，避免反复冻融。

关于BAMBI：
BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI) is a single-pass type I membrane protein that belongs to the BAMBI family. BAMBI is highly expression in kidney medulla, placenta and spleen. BAMBI is induced by BMP signaling through the evolutionary conserved BMP-responsive elements in its promoter. BAMBI plays important roles in signal transduction in many developmental and pathological processes. BAMBI transcription is activated by Wnt/beta-catenin signaling then its expression is aberrantly elevated in most colorectal carcinomas. BAMBI stably associates with TGF-β-family receptors and inhibits BMP and activin as well as TGF-β signalling. BAMBI negatively regulates TGF-β-family signalling by a regulatory mechanism involving the interaction of signalling receptors with a pseudoreceptor.