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文献和实验Anti-PEG IgM Production via a PEGylated Nano-Carrier System for Nucleic Acid Delivery
their long-circulating properties when they are injected repeatedly at certain intervals in the same animal. This unexpected and undesirable phenomenon is referred to as the accelerated blood clearance (ABC) phenomenon. Anti-PEG IgM produced in response
(2 ). Natural autoantibodies crossreact with a variety of conserved, and seemingly unrelated, autoantigens. Most of these antibodies are of low affinity, although rare exceptions of high affinity natural anti-DNA antibodies have been reported (3 ). The role
Transposon Tagging with AC/Ds in Arabidopsis
Transposon tagging provides an effective method of isolating plant genes by identifying a mutation tagged by a DNA insertion, and then using the DNA tag to isolate the mutant gene (reviewed m ref. I ). The first examples of this approach
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