重组人外切酶体成分9

产品英文名称：
Recombinant Human Exosome Component 9

英文简称:
EXOSC9

中文名称:
重组人外切酶体成分9

背景资料:
EXOSC9 is a non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and take part in many cellular RNA processing and degradation events. In the nucleus， the RNA exosome complex take part in proper maturation of stable RNA species like rRNA， snRNA and snoRNA， in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts like anti-sense RNA species and promoter-upstream transcripts （PROMPTs）， and of mRNAs with processing defects， thereby limiting or excluding their export to the cytoplasm. The RNA exosome is involved in Ig class switch recombination （CSR） and/or Ig variable region somatic hypermutation （SHM） by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm， the RNA exosome complex takes part in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements （AREs） within their 3’ untranslated regions， and in RNA surveillance pathways， inhibiting translation of aberrant mRNAs. EXOSC9 takes part in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits （Exo-9） is proposed to be an essential part in the binding and presentation of RNA for ribonucleolysis， and acts as a scaSf9 昆虫细胞重组表达old for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.

产品描述:
EXOSC9 is a Full-length cDNA coding for the human PM/Scl 75c-beta isoform having a molecular mass of 64 KDa. EXOSC9 protein is fused to a hexa-histidine purification tag.
来源宿主:
Sf9 昆虫细胞重组表达

序列:


溶解建议:
提供的重组人外切酶体成分9产品形式为经无菌过滤处理的无色溶液.

保存建议：
重组人外切酶体成分9产品在4℃保存请2 - 4周内将使用；-20℃可长期保存.避免反复冻融.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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