背景资料: MITF is a basic helix-loop-helix-leucin zipper (b-HLH-ZIP) transtripotion factor implicated in pigmentation, mast cells and bone development. The mutation of MITF causes Waardenburg Syndrome type II and Tietz syndrome in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of MITF di大肠杆菌中重组表达ering by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer MITF form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.
产品描述: MITF Human Recombinant (aa 170-279) expressed in E.coli, shows a 38 kDa band on SDS-PAGE(Including GST).The MITF is purified by proprietary chromatographic techniques.
来源宿主: 大肠杆菌中重组表达
序列:
溶解建议: Sterile Filtered clear solution. MITF in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
保存建议: Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.
其他简介: