产品英文名称: Recombinant Human Growth Arrest and DNA-Damage-Inducible Beta
英文简称: GADD45B
中文名称: 重组人生长停滞和DNA损伤可诱导蛋白β
背景资料: GADD45B is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45B reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45B is involved in the regulation of growth and apoptosis. GADD45b takes part during chondrocyte terminal di大肠杆菌中重组表达erentiation and mediates MMP-13 gene expression. GADD45 in B cells is induced by CD40 via a mechanism that involves NF-kappa B and that induction suppresses Fas-mediated killing. GADD45b is down-regulated in most cases of hepatocellular carcinoma (HCC), and is a molecular marker in the diagnosis of HCC and as a possible therapeutic target.
产品描述: GADD45B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 160 amino acids and having a molecular mass of 17.8 kDa.
来源宿主: 大肠杆菌中重组表达
溶解建议: Sterile Filtered colorless solution. The GADD45B protein solution contains 20mM Tris-HCl pH-7.5 and 20% glycerol.
保存建议: GADD45beta although stable 4℃ for 4 weeks, should be stored desiccated below -18℃.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
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