产品描述: Plasma fibronectin level is elevated in severe coronary artery disease. Increased plasma fibronectin levels are related with venous thromboembolism (VTE) particularly in males, and extend the probable association between biomarkers and risk factors for arterial atherothrombosis and VTE. Fibronectin plays a role in several cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/adhesion. Fibronectin consists in two main forms: 1) as an insoluble glycoprotein dimer that serves as a linker in the etracellular matrix and 2) as a soluble disulphide linked dimer found in the plasma. The plasma form is produced by hepatocytes, and the ECM form is synthesized by fibroblasts, chondrocytes, endothelial cells, macrophages, as well as certain epithelial cells. Fibronectin alos takes part as a general cell adhesion molecule by anchoring cells to collagen or proteoglycan substrates. Fibronectin organizes cellular interaction with the ECM by binding to di人血浆中提取纯化erent components of the extracellular matrix and to membrane-bound Fibronectin receptors on cell surfaces. Molecular Weight 450kDa.
来源宿主: 人血浆中提取纯化
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溶解建议: Sterile Filtered White lyophilized (freeze-dried) powder. The Fibronectin was lyophilized from a concentrated 1mg/ml solution containing 0.05M Tris HCl pH-7.5 and 0.1M NaCl. Purified fibronectin has a tendency to form insoluble aggregates upon reconstitution. We suggest to reconstittue the 1mg Fibronectin with a chaotropic agent such as urea at room temperature at a concentration of 0.2mg/ml using sterile water.Let stand 1-2 hours.
保存建议: Lyophilized Fibronectin although stable at room temperature for 1 week, should be stored desiccated below -18℃.Upon reconstitution Fibronectin should be stored at 4℃ between 2-7 days and for future use below -18℃.Please prevent freeze-thaw cycles.
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