人肝铁蛋白

产品英文名称：
Human Liver Ferritin

英文简称:
Ferritin

中文名称:
人肝铁蛋白

背景资料:
Ferritin is the main intracellular iron storage protein in prokaryotes and eukaryotes. Ferritin’s major functions are the storage of iron in a soluble and nontoxic state and its release in a controlled fashion. An iron-containing protein complex is found mostly in the intestinal mucosa， splFerritin is a glycoprotein produced in Human Liver having a molecular mass of 440- 450kDa and pI of 5.5， which stores iron atoms in the ferric state. It is predominantly intracellular， where it forms an exchangeable pool of iron acting as an iron store. Ferritin level in serum is directly proportional to body iron stores and serum levels are an excellent indicator in monitoring iron status in anemia. It can be used as a marker for inflammation and also used for monitoring and prediction of future events in coronary artery disease.n， and liver. Ferritin is composed of 24 subunits of the heavy and light chains. Variation in ferritin subunit composition may influence the rates of iron uptake and release in di人肝脏组织中提取纯化erent tissues. Defects in the light chain ferritin gene are linked to a number of neurodegenerative diseases and hyperferritinemia-cataract syndrome. The genes that encode the light and heavy chains are on located di人肝脏组织中提取纯化erent chromosomes. The light chain genes are in chromosome region 19q13.3-q13.4 whilst those for the heavy chain are in chromosome region 11q12-q13. Ferritin is shaped like a hollow sphere， inside which the iron is stored in the Fe（III） oxidation state. The iron is integrated in the mineral ferrihydrite， [FeO（OH）]8[FeO（H2PO4）]， which is attached to the inner wall of the sphere. To release iron once the body nFerritin is a glycoprotein produced in Human Liver having a molecular mass of 440- 450kDa and pI of 5.5， which stores iron atoms in the ferric state. It is predominantly intracellular， where it forms an exchangeable pool of iron acting as an iron store. Ferritin level in serum is directly proportional to body iron stores and serum levels are an excellent indicator in monitoring iron status in anemia. It can be used as a marker for inflammation and also used for monitoring and prediction of future events in coronary artery disease.ds it， the iron must be altered from the Fe（III） to the Fe（II） oxidation state. Subsequently， the iron leaves through channels in the spherical structure. Therefore， the structure of ferritin is tremendously important for the protein’s ability to store and release iron in a controlled mode. The amount of ferritin in the blood （serum ferritin level） is directly related to the amount of iron stored in the body. The body has a "bu人肝脏组织中提取纯化er" against iron deficiency （if the blood has too little iron， ferritin can release more） and， to a lesser extent， iron overload （if the blood and tissues of the body have too much iron， ferritin can help store the excess iron）.

产品描述:
Ferritin is a glycoprotein produced in Human Liver having a molecular mass of 440- 450kDa and pI of 5.5， which stores iron atoms in the ferric state. It is predominantly intracellular， where it forms an exchangeable pool of iron acting as an iron store. Ferritin level in serum is directly proportional to body iron stores and serum levels are an excellent indicator in monitoring iron status in anemia. It can be used as a marker for inflammation and also used for monitoring and prediction of future events in coronary artery disease.
来源宿主:
人肝脏组织中提取纯化

序列:


溶解建议:
Sterile Filtered brownish solution. The protein solution is in 0.05M TRIS buffer pH 7.5 containing 1.0M NaCl and 0.09% NaN3.

保存建议：
Human Ferritin should be stored at 2-8℃.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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