产品英文名称: Recombinant Human 3(2) 5-Bisphosphate Nucleotidase 1
英文简称: BPNT1
中文名称: 重组人3’,5’-二磷酸核苷酸酶1
背景资料: BPNT1 belongs to the magnesium-dependent, lithium-sensitive phosphomono-esterase superfamily. BPNT1 catalyzes the conversion of PAPS(adenosine 3’-phosphate 5’ phosphosulfate) to APS(adenosine 5’-phosphosulfate) and the conversion of PAP(3’(2’)-phosphoadenosine 5’ phosphate) to AMP(adenosine 5’-phosphate) using magnesium as a cofactor. BPNT1 is expressed everywhere but at maximum levels in brain and kidney. BPNT1 is potently inhibited by lithium, a drug used for the treatment of manic depression and bipolar a大肠杆菌中重组表达ective disorder, which suMRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASS NTVLMRLVAS AYSIAQKAGM IVRRVIAEGD LGIVEKTCAT DLQTKADRLA QMSICSSLAR KFPKLTIIGE EDLPSEEVDQ ELIEDSQWEE ILKQPCPSQY SAIKEEDLVV WVDPLDGTKE YTEGLLDNVT VLIGIAYEGK AIAGVINQPY YNYEAGPDAV LGRTIWGVLG LGAFGFQLKE VPAGKHIITT TRSHSNKLVT DCVAAMNPDA VLRVGGAGNK IIQLIEGKAS AYVFASPGCK KWDTCAPEVI LHAVGGKLTD IHGNVLQYHK DVKHMNSAGV LATLRNYDYY ASRVPESIKN ALVPests that BPNT1 has a possible role in the etiology of mood disorders.
产品描述: BPNT1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 344 amino acids(1-308a.a.) and having a molecular mass of 37.5kDa.BPNT1 is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
来源宿主: 大肠杆菌中重组表达