产品英文名称: Recombinant Human Precursor Brain-Derived Neurotrophic Factor
英文简称: proBDNF
中文名称: 重组人脑源性神经营养因子前体蛋白
背景资料: proBDNF (the precursor form of Brain-derived neurotrophic factor) interacts preferentially with p75NTR (the pan-neurotrophin receptor p75) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis,while the mature BDNF selectively binds with great a大肠杆菌重组表达inity to the TrkB kinase receptor and promotes the survival,growth and di大肠杆菌重组表达erentiation of neurons. Since proneurotrophins and mature neurotrophins bring forth opposite biological e大肠杆菌重组表达ects,proBDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. proBDNF has an important role in negative regulation of neurotrophic actions in the brain.
产品描述: proBDNF Human Recombinant produced in E.Coli is a single,non-glycosylated,non-covalently linked homodimer with each polypeptide chain containing 229 amino acids and having a molecular mass of 52kDa. The proBDNF is purified by proprietary chromatographic techniques.
来源宿主: 大肠杆菌重组表达
序列: The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Pro-Met-Lys.