产品英文名称: Recombinant Human Tumor Necrosis Factor Receptor Type 1
英文简称: TNFR1
中文名称: 重组人1型肿瘤坏死因子受体
背景资料: TNFR1 belongs to the TNF-receptor superfamily. TNFR1 is a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. There are 2 types of soluble TNF receptors: sTNFR-I and sTNFR-II,which act to neutralize the biological activities of TNF alpha and TNF beta. The levels of these soluble receptors s人1型肿瘤坏死因子受体重组蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有162个氨基酸,分子量为18.2kDa.该人1型肿瘤坏死因子受体重组蛋白最终由标准的色谱技术纯化出.m to increase as a result of shedding of the extracellular domains of the membrane bound receptors. TNF-a,TNFR1 and TNFR2 have roles in cellular di大肠杆菌中重组表达erentiation. TNFR1 and TNFR2 function in cell type-specific renal injury. TNFR1 is capable of signaling both cell survival and apoptosis. TNFR1-induced apoptosis requires 2 sequential signaling complexes. TNFR1 is capable of activating NF-kappaB,mediate apoptosis,and function as a regulator of inflammation. Oxidative stress promotes TNFR1 and TNFR2 self-interaction,ligand-independent and enhanced ligand-dependent TNF signaling. TNFR1 contributes to the induction of non-cytocidal TNF e大肠杆菌中重组表达ects including anti-viral state and ac