人结合珠蛋白

产品英文名称：
Recombinant Human Haptoglobin

英文简称:
Haptoglobin

中文名称:
重组人结合珠蛋白

背景资料:
Haptoglobin is a glycoprotein which is synthesized in the liver and circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin， lung， and kidney. It is a positive acute phase protein that binds frHaptoglobin Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing （aa. 145-405） fusion protein with His tag and having a total Mw of 33 kDa （4 kDa His-tag）. hemoglobin and removes it from the circulation to prevent kidney injury， and iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system （generally the splHaptoglobin Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing （aa. 145-405） fusion protein with His tag and having a total Mw of 33 kDa （4 kDa His-tag）.n）. As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body， haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin， haptoglobin sequesters the iron inside hemoglobin， preventing iron-utilizing bacteria from benefitting from hemolysis. Haptoglobin consists of two ?- and two ?-chains， connected by disulfide bonds. ThrHaptoglobin Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing （aa. 145-405） fusion protein with His tag and having a total Mw of 33 kDa （4 kDa His-tag）. major haptoglobin phenotypes are known to exist （Hp 1-1， Hp 2-1， and Hp 2-2）. Hp 1-1 is biologically the most e大肠杆菌中重组表达ective in binding frHaptoglobin Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing （aa. 145-405） fusion protein with His tag and having a total Mw of 33 kDa （4 kDa His-tag）. hemoglobin and suppressing inflammatory responses associated with frHaptoglobin Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing （aa. 145-405） fusion protein with His tag and having a total Mw of 33 kDa （4 kDa His-tag）. hemoglobin. Hp 2-2 is biologically the least active， and Hp 2-1 is moderately active. Haptoglobin’s molecular mass ranges from 8-200 kDa. Reduced levels can be sHaptoglobin Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing （aa. 145-405） fusion protein with His tag and having a total Mw of 33 kDa （4 kDa His-tag）.n in haemolysis and impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy， the incidence of coronary artery disease in type 1 diabetes， Crohn’s disease， inflammatory disease behavior， primary sclerosing cholangitis， susceptibility to idiopathic Parkinson’s disease， and a reduced incidence of Plasmodium falciparum malaria.

产品描述:
Haptoglobin Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing （aa. 145-405） fusion protein with His tag and having a total Mw of 33 kDa （4 kDa His-tag）.
来源宿主:
大肠杆菌中重组表达

序列:


溶解建议:
Sterile Filtered White lyophilized （freeze-dried） powder. Each mg was lyophilized with 1xPBS， 0.1% SDS and 1mM DTT. It is recommended to reconstitute the lyophilized Haptoglobin in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.

保存建议：
Lyophilized Haptoglobin although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Haptoglobin should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。